A molecular tug-of-war: Global plant proteome changes during viral infection

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• 作者：Mariko M. Alexander^a ; ^b ; Michelle Cilia^a ; ^b ; ^c ; ^{michelle.cilia@ars.usda.gov" class="auth_mail" title="E-mail the corresponding author} ; ^{mlc68@cornell.edu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：2D DIGE ; two dimensional difference in gel electrophoresis ; BNYVV ; Beet necrotic yellow vein virus ; BYV ; Beet yellows virus ; CABYV ; Cucurbit aphid-borne yellows virus ; CaLCuV ; Cabbage leaf curl virus ; CaMV ; Cauliflower mosaic virus ; CLCuV ; Cotton leaf curl virus ; CMV ; Cucumber mosaic virus ; CSDaV ; Citrus sudden death-associated virus ; CYDV-RPV ; Cereal yellow dwarf virus ; RPV strain ; CymMV ; Cymbidium mosaic virus ; ER ; endoplasmic reticulum ; GAPDH ; glyceraldehyde-3-phosphate dehydrogenase ; GFLV ; G
• 刊名：Current Plant Biology
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：5
• 期：Complete
• 页码：13-24
• 全文大小：1454 K

文摘

Plant pathogenic viruses cause a number of economically important diseases in food, fuel, and fiber crops worldwide. As obligate parasites with highly reduced genomes, viruses rely heavily on their hosts for replication, assembly, intra- and intercellular movement, and attraction of vectors for dispersal. Therefore, viruses must influence or directly utilize many host proteins and processes. While many general effects of virus infection have long been known (e.g., reduction in photosynthesis, alterations in carbon metabolism and partitioning, increased expression of pathogenesis-related proteins), the precise underlying mechanisms and functions in the viral life cycle are largely a mystery. Proteomic studies, including studies of differential protein regulation during infection as well as studies of host–viral protein–protein interactions, can help shed light on the complex and varied molecular interactions between viruses and plant hosts. In this review, we summarize current literature in plant-virus proteomics and speculate on why viruses have been selected to manipulate these diverse biochemical pathways in their plant hosts.