Biotransformation of OH-PBDEs by pig liver microsomes: Investigating kinetics, identifying metabolites, and examining the role of different CYP isoforms
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- 作者：Jianhua Lia ; Ya Zhangb ; Zhongkun Dua ; Jianbiao Penga ; Liang Maoa ; Shixiang Gaoa ; ecsxg@nju.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Hydroxylated polybrominated diphenyl ethers ; Biotransformation ; Pig liver microsomes ; Enzyme
- 刊名：Chemosphere
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：148
- 期：Complete
- 页码：354-360
- 全文大小：727 K
文摘
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OH-PBDEs were more readily metabolized by pig liver microsomes than PBDEs.
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Biotransformation rates of OH-PBDEs decreased with increasing bromine substitution.
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CYP3A4 was suggested to be the primary isoform responsible for OH-PBDEs metabolism.
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Metabolism pathways included ether cleavage, hydroxylation, and debromination.
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Yield of 2,4-DBP was higher than those of 4-BP and 2-BP.