“Hockey Stick” may Strike Back: Hepatocellular Carcinoma on Noncirrhotic Liver as a Late Toxicity of Lombo-Aortic Radiotherapy for Seminoma. A Review Triggered by an Unusual Case

详细信息    查看全文

• 作者：Clement Korenbaum^* ; ^{clement.korenbaum@chru-strasbourg.fr" class="auth_mail" title="E-mail the corresponding author} ; Philippe Barthelemy^* ; Alina Onea^* ; ^&dagger ; ; Pierre Salze^&dagger ; ; Jean-Emmanuel Kurtz^*
• 关键词：CT ; computed tomography ; NASH ; nonalcoholic steato-hepatitis ; SEER ; Surveillance ; Epidemiology and End Results ; TGCT ; testicular germ cell tumor ; US ; ultrasound
• 刊名：Journal of Clinical and Experimental Hepatology
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：6
• 期：1
• 页码：54-58
• 全文大小：1196 K

文摘

Most patients with testicular seminoma have been treated with a curative intent for decades. Second cancers after radiotherapy for testicular seminoma before 1990 are a growing issue, and are related to previous generation of dose planning and delineating strategies. Among those cancers, hepatocellular carcinoma is an extremely rare occurrence, especially when affecting patients with healthy, noncirrhotic liver. Here, we describe such a case in a patient of our institution, and subsequently review the relevant literature and large epidemiologic studies. Understanding those late and serious toxicity features may help cancer care teams to screen and treat those patients appropriately.