Lack of association between antipsychotic-induced extrapyramidal symptoms and polymorphisms in dopamine metabolism and transport genes

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• 作者：Patricia Gassó ; Sergi Mas ; Anna Crescenti ; Santi Á ; lvarez ; Gemma Parramon ; Clemente Garcia-Rizo ; Eduard Parellada ; Miquel Bernardo ; Amalia Lafuente
• 关键词：Pharmacogenetics ; Extrapyramidal symptoms ; Antipsychotic
• 刊名：Psychiatry Research
• 出版年：2010
• 出版时间：30 January 2010
• 年：2010
• 卷：175
• 期：1-2
• 页码：173-175
• 全文大小：123 K

文摘

The purpose of this study was to investigate the relationship between functional polymorphisms in genes coding for dopamine metabolism and transport enzymes and the incidence of acute antipsychotic (AP)-induced extrapyramidal symptoms (EPS). We did not find evidence of the involvement of these polymorphisms in the predisposition towards or protection from EPS.