Clenbuterol activates the central IL-1 system via the β2-adrenoceptor without provoking inflammatory response related behaviours in rats
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- 作者：Karen M. Ryana ; 1 ; É ; adaoin W. Griffina ; 1 ; Katie J. Ryana ; Riffat Tanveera ; Natacha Vanattou-Saifoudineb ; Eoin N. McNameea ; Emer Fallona ; Sheena Heffernana ; Andrew Harkinb ; aharkin@tcd.ie" class="auth_mail" title="E-mail the corresponding author ; Thomas J. Connora ; &dagger ;
- 关键词：β2-Adrenoceptor ; Clenbuterol ; Cytokine ; IL-1β ; Locomotor activity ; Food consumption ; Sickness behaviour ; Anhedonia ; Anxiety ; Depression
- 刊名：Brain, Behavior, and Immunity
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：56
- 期：Complete
- 页码：114-129
- 全文大小：3181 K
文摘
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Clenbuterol induces selective expression of the IL-1 system in the CNS.
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Clenbuterol does not induce a classical neuroinflammatory or sickness response.
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Peripheral effects of clenbuterol can be dissociated from central effects.
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Repeated low dose clenbuterol does not induce depressive or anxiety-like behaviour.