Rapid Analysis of Trace Salbutamol and Clenbuterol in Pork Samples by Mass Spectrometry

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• 作者：Yi-Po XIAO^a ; Hai-Yan LU^a ; Shao-Jun LÜ ; ^b ; Shao-Xian XIE^b ; Zhao-Zheng WANG^b ; Huan-Wen CHEN^a ; ^{chw8868@gmail.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Internal extraction electrospray ionization ; Salbutamol ; Clenbuterol ; β-Agonists ; Organizational analysis
• 刊名：Chinese Journal of Analytical Chemistry
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：44
• 期：11
• 页码：1633-1638
• 全文大小：597 K

文摘

Salbutamol and clenbuterol as β-agonists are illegally added in pig feed, resulting in pork contaminated and even leading excessive excitability of athletes. Therefore, it has a great significance for establishing a new rapid detection method of salbutamol and clenbuterol in pork. In this study, internal extraction electrospray ionization mass spectrometry (iEESI-MS) technique was used for directly qualitative and quantitative analysis of salbutamol and clenbuterol in pork tissues without any sample pretreatment. The results showed that this method had a high sensitivity to salbutamol and clenbuterol analysis with detection limits of (LOD) 6.2 and 9.8 ng kg⁻¹, respectively, while the analysis time for detecting single sample and single index was less than 30 s. In a range of 0.01–1000 μg kg⁻¹, the logarithm of signal intensity (Y) and the logarithm of concentration (X) had a good linear relationship. This method had many advantages such as rapid analysis, low sample consumption and high sensitivity, which was ideal for the rapid detection of trace salbutamol and clenbuterol.