Atrial fibrillation, cognitive impairment, and neuroimaging

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• 作者：Jonathan Graff-Radford^a ; Malini Madhavan^b ; Prashanthi Vemuri^c ; Alejandro A. Rabinstein^a ; Ruth H. Cha^d ; Michelle M. Mielke^a ; ^d ; Kejal Kantarci^c ; Val Lowe^c ; Matthew L. Senjem^c ; Jeffrey L. Gunter^c ; David S. Knopman^a ; Ronald C. Petersen^a ; Clifford R. Jack Jr.^d ; Rosebud O. Roberts^a ; ^d ; ^{roberts.rosebud@mayo.edu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Atrial fibrillation ; Mild cognitive impairment ; Stroke ; Alzheimer's disease ; Cerebrovascular disease
• 刊名：Alzheimer's & Dementia
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：12
• 期：4
• 页码：391-398
• 全文大小：450 K

文摘

The objective of our study was to investigate cross-sectional associations of atrial fibrillation with neuroimaging measures of cerebrovascular disease and Alzheimer's disease and their interactions with mild cognitive impairment (MCI).

Methods

Magnetic resonance imaging scans of individuals from a population-based study were analyzed for infarctions, total gray matter, and hippocampal and white matter hyperintensity volumes. A subsample underwent positron emission tomography imaging.

Results

Atrial fibrillation was associated with infarctions and lower total gray matter volume. Compared with subjects with no atrial fibrillation and no infarction, the odds ratio (95% confidence intervals) for MCI was 2.99 (1.57–5.70; P = .001) among participants with atrial fibrillation and infarction, 0.90 (0.45–1.80; P = .77) for atrial fibrillation and no infarction, and 1.50 (0.96–2.34; P = .08) for no atrial fibrillation and any infarction.

Discussion

Participants with both atrial fibrillation and infarction are more likely to have MCI than participants with either infarction or atrial fibrillation alone.