Levels of tau protein in plasma are associated with neurodegeneration and cognitive function in a population-based elderly cohort

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• 作者：Jeffrey L. Dage^a ; Alexandra M.V. Wennberg^b ; David C. Airey^a ; Clinton E. Hagen^c ; David S. Knopman^d ; Mary M. Machulda^e ; Rosebud O. Roberts^b ; ^d ; Clifford R. Jack Jr.^f ; Ronald C. Petersen^d ; Michelle M. Mielke^b ; ^d ; ^{mielke.michelle@mayo.edu}
• 关键词：Plasma tau ; Amyloid ; Cortical thickness ; MCI ; Cognition ; Memory ; MRI
• 刊名：Alzheimer's & Dementia
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：12
• 期：12
• 页码：1226-1234
• 全文大小：592 K
• 卷排序：12

文摘

Higher plasma tau levels were cross sectionally associated with worse memory performance and lower cortical thickness in an Alzheimer's disease (AD) signature region. In analyses comparing eight groups defined by cognitive status and neuroimaging measures, there was high overlap in plasma tau levels. These results suggest that plasma tau will not be useful as a stand-alone diagnostic biomarker in preclinical or prodromal AD. Future studies are needed to evaluate the longitudinal associations between plasma tau and neuroimaging measures of amyloid and neurodegeneration in the preclinical and clinical AD stages. This research is critical to assess the utility of plasma tau as a prognostic marker, for use in clinical trials, or for patient management.