Splenic Dendritic Cells Survey Red Blood Cells for Missing Self-CD47 to Trigger Adaptive Immune Responses
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- 作者：Tangsheng Yi1 ; 3 ; Jianhua Li1 ; Hsin Chen1 ; Jiaxi Wu1 ; Jinping An1 ; Ying Xu1 ; Yongmei Hu2 ; Clifford A. Lowell2 ; Jason G. Cyster1 ; jason.cyster@ucsf.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Immunity
- 出版年：2015
- 出版时间：20 October 2015
- 年：2015
- 卷：43
- 期：4
- 页码：764-775
- 全文大小：4958 K
文摘
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SRBC adjuvant effect involves splenic DC activation by missing-self recognition
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CD47-deficient mouse RBCs have SRBC-like adjuvant activity
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Chronic DC activation in CD47-deficient mice might explain splenic DC deficiency
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RBC-triggered DC activation occurs via Src-family kinases and involves integrins