c-Abl and Src-family kinases cross-talk in regulation of myeloid cell migration
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- 作者：Anna Baruzzi ; Ilaria Iacobucci ; Simona Soverini ; Clifford A. Lowell ; Giovanni Martinelli ; Giorgio Berton
- 关键词：Macrophage ; Neutrophil ; Tyrosine kinase ; Chemotaxis ; Signal transduction
- 刊名：FEBS Letters
- 出版年：2010
- 出版时间：4 January 2010
- 年：2010
- 卷：584
- 期：1
- 页码：15-21
- 全文大小：611 K
文摘
Cytoskeleton dynamics are regulated by Src-family tyrosine kinases (SFKs) and c-Abl. We found that the SFK members Hck and c-Fgr regulate tyrosine phosphorylation of c-Abl and c-Abl associates with β1 integrin-bound Hck or c-Fgr in murine macrophages. Studies with selective inhibitors and cells from SFK-deficient mice showed that c-Abl and SFK regulate migration and activation of the small GTPases Cdc42 and Rac in macrophages. Additionally, human neutrophil chemotactic activity was reduced by c-Abl inhibitors, and neutrophils from chronic myeloid leukaemia patients displayed an increased chemotactic ability. Hence, Src-family kinase and c-Abl cross-talk in the regulation of myeloid cell migration.
ass=""h4"">Structured summary
MINT-7296608: Integrin beta-1 (uniprotkb:P09055) physically interacts (MI:0914) with Hck (uniprotkb:P08103), Abl (uniprotkb:P00520) and Fgr (uniprotkb:P14234) by anti bait coimmunoprecipitation (MI:0006) MINT-7296596: Integrin beta-1 (uniprotkb:P09055) physically interacts (MI:0914) with Fgr (uniprotkb:P14234) and Abl (uniprotkb:P00520) by anti bait coimmunoprecipitation (MI:0006)