Epigenetic dysregulation of interleukin 8 (CXCL8) hypersecretion in cystic fibrosis airway epithelial cells
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- 作者：Anna Poghosyan ; pannagos@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; Jamie K. Patel ; Rachel L. Clifford ; Alan J. Knox ; alan.knox@nottingham.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：CF ; Epigenetics ; CXCL8 ; BRD4
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：5 August 2016
- 年：2016
- 卷：476
- 期：4
- 页码：431-437
- 全文大小：1183 K
文摘
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A regulatory mechanism of CXCL8 transcriptional control in CF airways is proposed.
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There was an increased binding of NF-κB and C/EBPβ transcription factors.
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There was enhanced recruitment of BET proteins to the CXCL8 promoter.
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Epigenetic modifications are responsible for the aberrant CXCL8 transcription.