A putative role for apelin in the etiology of obesity
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- 作者：Srujana Rayalam ; Mary Anne Della-Fera ; Paul A. Krieg ; Christopher M. Cox ; Allan Robins ; Clifton A. Baile
- 关键词：Apelin ; Angiogenesis ; Adipose tissue ; Adiposity ; APJ receptor ; Obesity ; Endothelial cells
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2008
- 出版时间：11 April 2008
- 年：2008
- 卷：368
- 期：3
- 页码：815-819
- 全文大小：355 K
文摘
Apelin, the endogenous ligand of the G protein-coupled APJ receptor has been shown to promote tumor angiogenesis. However, the effect of apelin on inducing angiogenesis in adipose tissue has not been investigated. In this review, we propose a putative role for apelin in promoting angiogenesis in adipose tissue. We further propose that targeting adipose tissue vasculature by blocking apelin signaling with anti-apelin antibodies will lead not only to inhibition of angiogenesis in adipose tissue but also to decreased adiposity.