A novel natural hirudin facilitated anti-clotting polylactide membrane via hydrogen bonding interaction

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• 作者：Jinglong Li^a ; ^b ; Fu Liu^a ; ^{fu.liu@nimte.ac.cn} ; Yan Qin^a ; Jidong He^b ; Zhu Xiong^a ; Gang Deng^c ; Qiang Li^d
• 关键词：Hirudin ; PLA membrane ; Hemocompatibility ; Anti-clotting ; Dialysis
• 刊名：Journal of Membrane Science
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：523
• 期：Complete
• 页码：505-514
• 全文大小：1577 K
• 卷排序：523

文摘

Natural hirudin was immobilized on PLA membrane via hydrogen bonding. The surface crosslinked PVP provided attaching spacer. PVP/hirudin complex shows desired anti-clotting stability and activity. The PLA membrane showed excellent dialysis capability.