Clusterin in the protein corona plays a key role in the stealth effect of nanoparticles against phagocytes
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- 作者：Michihiko Aoyamaa ; 1 ; Katsutomo Hataa ; 1 ; Kazuma Higashisakaa ; Kazuya Naganoa ; Yasuo Yoshiokaa ; b ; c ; y-yoshioka@biken.osaka-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Yasuo Tsutsumia ; d ; ytsutsumi@phs.osaka-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：Silver nanoparticle ; Silica nanoparticle ; Protein corona ; Clusterin ; Cellular uptake ; Phagocyte
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：25 November 2016
- 年：2016
- 卷：480
- 期：4
- 页码：690-695
- 全文大小：763 K
文摘
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Protein corona inhibit the uptake of silver or silica nanoparticles by phagocytes.
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Clusterin levels were higher in plasma-protein corona than in serum-protein corona.
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Clusterin inhibited the cellular uptake of silver or silica nanoparticles.