High-order TRAIL oligomer formation in TRAIL-coated lipid nanoparticles enhances DR5 cross-linking and increases antitumour effect against colon cancer
详细信息 查看全文
- 作者：Diego De Miguela ; b ; 1 ; diego_demiguel@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Ana Gallego-Lleydaa ; b ; José ; Marí ; a Ayusob ; c ; d ; Dolores Pejenaute-Ochoaa ; Vidal Jarautaa ; Isabel Marzoa ; b ; Luis J. Ferná ; ndezb ; c ; d ; Ignacio Ochoab ; c ; d ; Blanca Condee ; Alberto Anela ; b ; Luis Martinez-Lostaoa ; b ; f ; 2 ; lumartin@unizar.es" class="auth_mail" title="E-mail the corresponding author
- 关键词：TRAIL ; Colorectal cancer ; Lipid nanoparticles ; Immunotherapy ; DR5 cross-linking
- 刊名：Cancer Letters
- 出版年：2016
- 出版时间：28 December 2016
- 年：2016
- 卷：383
- 期：2
- 页码：250-260
- 全文大小：1903 K
文摘
- •
Liposomes with TRAIL show greater cytotoxicity than soluble TRAIL in colon cancer cells.
- •
Liposomes with TRAIL overcome resistance to soluble TRAIL in colon cancer cells.
- •
TRAIL anchored to liposome surface form high-order oligomers which in turn, induce a more potent clusterization of DR5.
- •
Liposomes with TRAIL show greater in vivo anti-tumour activity than soluble TRAIL.