An Mcm10 Mutant Defective in ssDNA Binding Shows Defects in DNA Replication Initiation
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- 作者：Patricia Perez-Arnaiz1 ; Daniel L. Kaplan ; Daniel.Kaplan@med.fsu.edu" class="auth_mail" title="E-mail the corresponding author ; daniel_l_kaplan@yahoo.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：GINS ; Go ; Ichi ; Ni ; and San ; CMG ; Cdc45 ; the heterohexameric Mcm2&ndash ; 7 complex ; and the tetrameric GINS ; CDK ; cyclin-dependent kinase ; DDK ; Dbf4-dependent kinase ; dsDNA ; double-stranded DNA ; ssDNA ; single-stranded DNA ; ID ; internal domain ; RPA ; replication protein A ; ChIP ; chromatin immunoprecipitation ; GST ; glutathione S-transferase ; IAA ; indole-3-acetic ; FACS ; fluorescence-activated cell sorting ; PKA ; protein kinase A ; ORC ; origin recognition complex ; BSA ; bovine serum albumin
- 刊名：Journal of Molecular Biology
- 出版年：2016
- 出版时间：20 November 2016
- 年：2016
- 卷：428
- 期：23
- 页码：4608-4625
- 全文大小：1366 K
文摘
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Mcm10 is an essential protein for DNA replication initiation in eukaryotes.
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The interaction between Mcm10 and DNA is essential for the function of Mcm10 during DNA replication initiation.