Altered dendritic cell subset distribution in patients with Parkinson's disease: Impact of CMV serostatus
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- 作者：David Goldecka ; david.goldeck@uni-tuebingen.de" class="auth_mail" title="E-mail the corresponding author ; Walter Maetzlerb ; c ; Daniela Bergb ; c ; Lilly Oettingera ; Graham Paweleca ; d
- 关键词：α-syn ; alpha-synuclein ; CMV ; cytomegalovirus ; ILT ; Ig-like transcript ; mDC ; myeloid dendritic cells ; pDC ; plasmacytoid dendritic cells ; UPDRS ; unified Parkinson disease rating scale ; TLR ; toll-like receptor
- 刊名：Journal of Neuroimmunology
- 出版年：2016
- 出版时间：15 January 2016
- 年：2016
- 卷：290
- 期：Complete
- 页码：60-65
- 全文大小：638 K
文摘
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Frequencies of plasmacytoid DCs were similar in PD patients and controls.
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Frequencies of pro-inflammatory CD16+ILT2high myeloid DCs were higher in CMV-positive PD patients than CMV-positive controls.
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ILT2 expression on myeloid DCs positively correlated with total UPDRS levels (p = 0.014) in CMV + PD patients.