KCNE2 modulates cardiac L-type Ca2 + channel
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- 作者：Wenjuan Liua ; 1 ; Jianxin Dengb ; 1 ; Gang Wanga ; 1 ; Cuicui Zhangc ; Xinping Luoa ; Dewen Yanb ; Qingning Sud ; Jie Liua ; ljljz@yahoo.com" class="auth_mail
- 关键词：LCC ; L-type Ca2 ; + channel ; LQT ; long-QT syndrome ; ICa ; L ; L-type Ca2 ; + current ; AF ; atrial fibrillation ; NTI ; N-terminal inhibitory module
- 刊名：Journal of Molecular and Cellular Cardiology
- 出版年：July 2014
- 年：2014
- 卷：72
- 期：Complete
- 页码：208-218
- 全文大小：2721 K
文摘
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KCNE2 regulates L-type Ca2 + current (ICa,L) in cardiomyocytes and in HEK 293 cells.
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KCNE2 physically interacts with Cav1.2, the 伪 subunit of ICa,L.
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The N terminal inhibitory module of Cav1.2 contributes to KCNE2 modulating ICa,L.
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KCNE2-R27C, a familial AF related mutation enhanced KCNE2 suppression of ICa,L.