Therapeutic effects of the Rho GTPase modulator CNF1 in a model of Parkinson’s disease
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- 作者：Marco Musillia ; Maria Teresa Ciottib ; Massimo Pieric ; Assunta Martinoa ; Sonia Borrellia ; Vincenzo Dinalloc ; Giovanni Dianaa ; giovanni.diana@iss.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：Rho ; Rac ; Cdc42 ; 6-Hydroxydopamine ; Neurodegeneration ; Bacterial toxins ; Bacteria
- 刊名：Neuropharmacology
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：109
- 期：Complete
- 页码：357-365
- 全文大小：1704 K
文摘
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Rho GTPases are involved in familial Parkinsonisms.
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The Rho GTPase modulator CNF1 shows efficacy in a model of Parkinson’s disease.
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We conclude that Rho GTPase signaling can be exploited to treat Parkinson’s disease.
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Naturally occurring Rho GTPase modulators may play a role in Parkinson’s disease.