- 作者：Hui Li ; Yong-Jun Wang ; Lin Hua ; Yu-Tao Yang ; Min Zhang ; Dabao Zhang ; Chuanyue Wang ; Zhi-Qing David Xu
- 关键词：DCNP1 ; Dendritic cell nuclear protein-1 ; MDD ; Major depressive disorder ; SNP ; single nucleotide polymorphism ; UK ; United Kingdom ; GWAS ; Genome-wide association ; SCID-D-CV ; DSM-IV Axis I disorders-Clinical Version ; HDRS ; Hamilton's depression Rating Scale
- 刊名：Progress in Neuro-Psychopharmacology and Biological Psychiatry
- 出版年：2013
- 出版时间：1 August, 2013
- 年：2013
- 卷：45
- 期：Complete
- 页码：7-10
- 全文大小：216 K
Objectives
Dendritic cell nuclear protein-1 (DCNP1) has been associated with major depressive disorder (MDD) based on analysis of a population of patients in the United Kingdom. In the present study we have investigated a possible role of DCNP in MDD in the Han Chinese population, including a meta-analysis of different ethnic populations.Methods
Eight single nucleotide polymorphisms (SNPs) spanning the entire DCNP1 were carefully selected, genotyped and used for the SNP and haplotype analyses in 574 patients with MDD and 642 healthy controls. Considering the potential genetic association difference across different ethnic populations, we further conducted a meta-analysis for Chinese and European populations.
Results
rs10061623 showed initial association with MDD in females in the allele analysis (p-value: 0.043). However, this association did not remain significant after Bonferroni correction to adjust for multiple comparisons (corrected p-value: 0.344). Other single-marker and haplotype analyses did not reveal any significant differences between patients and controls. The SNP (rs12520799), positive in the original UK study, gave negative results in all our analyses. The meta-analysis results of rs12520799 also suggested possible negative association between this SNP and MDD in the Han Chinese population.
Conclusions
In the Han Chinese population, common DCNP1 polymorphisms are unlikely to be important in the genetic susceptibility to MDD.