Genetics of long-term treatment outcome in bipolar disorder
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- 作者：Chiara Fabbri ; Alessandro Serretti ; alessandro.serretti@unibo.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：BD ; Bipolar Disorder ; STEP-BD ; Systematic Treatment Enhancement Program for Bipolar disorder ; DFNB31 ; Deafness ; Autosomal Recessive 31 ; SORCS2 ; Sortilin-Related VPS10 Domain Containing Receptor 2 ; NRXN1 ; Neurexin 1 ; CNTNAP2 ; Contactin Associated Protein-Like 2 ; GRIN2A ; Glutamate Receptor ; Ionotropic ; N-Methyl D-Aspartate 2A ; GRM4 ; Glutamate Receptor ; Metabotropic 4 ; GRIN2B ; Glutamate Receptor ; Ionotropic ; N-Methyl D-Aspartate 2B ; DEPTOR ; DEP Domain Containing MTOR-Interacting Protein ; CHRNA7 ; Ch
- 刊名：Progress in Neuropsychopharmacology & Biological Psychiatry
- 出版年：2016
- 出版时间：4 February 2016
- 年：2016
- 卷：65
- 期：Complete
- 页码：17-24
- 全文大小：523 K
文摘
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Genetic markers of long-term treatment outcome could improve the prognosis of bipolar disorder.
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Single SNPs and molecular pathways were analyzed in a genome-wide association study.
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TRAF3IP2-AS1, RNLS, DFNB31, NFYC and DEPTOR genes were predictors of total episode rate.
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The DFNB31 gene was strongly associated with the risk of depressive recurrence.
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Top pathways mediate the regulation of MAPK cascade and learning/memory processes.