文摘
This study tested the efficacy of carvedilol (CAR), an adrenergic blocker, for cocaine use disorder. Cocaine-dependent participants were randomized to placebo (n = 34), 25 mg/day CAR (n = 37) or 50 mg/day CAR (n = 35). Treatment with either 25 or 50 mg CAR did not reduce cocaine use more than placebo in methadone-maintained cocaine users. These results do not support the potential use of CAR for the treatment of CUD in patients maintained on methadone.