Novel structural features increase the antioxidant effect of estrogen analogues on low density lipoprotein
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- 作者：Alan F. Fidarova ; Veera Vihmab ; c ; veera.vihma@helsinki.fi" class="auth_mail" title="E-mail the corresponding author ; Roman P. Bogautdinova ; Svetlana N. Morozkinaa ; Alexander G. Shavvaa ; Matti J. Tikkanenb ; c
- 关键词：17β-E2 ; 17β-estradiol ; LDL ; low density lipoprotein ; Log P ; logarithm of the n-octanol/water partition coefficient ; SD ; standard deviation
- 刊名：Journal of Steroid Biochemistry and Molecular Biology
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：154
- 期：Complete
- 页码：142-149
- 全文大小：1858 K
文摘
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A six-carbon d-ring increased the antioxidant activity of estrogen analogues.
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Estrogen analogues with a fluorine atom at C-2 were potent antioxidants.
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Unsaturated analogues with a substituted 3-OH group inhibited lipid peroxidation.