Evaluation of the membrane permeability of drugs by ion-transfer voltammetry with the oil | water interface
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- 作者：Mayumi Nakamura ; Toshiyuki Osakai ; osakai@kobe-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：Drug permeability ; Oil ; | ; water interface ; Standard ion-transfer potential ; 1-Octanol&ndash ; water partition coefficient ; PAMPA
- 刊名：Journal of Electroanalytical Chemistry
- 出版年：2016
- 出版时间：15 October 2016
- 年：2016
- 卷：779
- 期：Complete
- 页码：55-60
- 全文大小：658 K
文摘
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Ion-transfer voltammetry was performed for amine drugs at the DCE | water interface.
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The standard ion-transfer potential is useful for predicting drug permeability.
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This index would be more available than log P in the octanol–water system.