Multicomponent synthesis of novel coelenterazine derivatives substituted at the C-3 position

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• 作者：Vito Vece ; ^{vece.imperiachemistry@outlook.com" class="auth_mail" title="E-mail the corresponding author} ; Giuseppina Vuocolo
• 关键词：Coelenterazine derivatives ; Multicomponent reaction ; tert-Butyl group cleavage ; Azoylidene carbene ; Hydrogen abstraction
• 刊名：Tetrahedron
• 出版年：2015
• 出版时间：18 November 2015
• 年：2015
• 卷：71
• 期：46
• 页码：8781-8785
• 全文大小：414 K

文摘

Three novel coelenterazine derivatives substituted at the C-3 position were synthesized through a multicomponent strategy based on Groebke–Blackburn–Bienaymé reaction without using protecting groups. An efficient one-pot tert-butyl group cleavage from an aminoimidazopirazine and the first example of direct diazoimidazole derivative hydrogen abstraction in acidified water (traditional Sandmeyer hydroxylation conditions) were described.