Cardanol-derived AChE inhibitors: Towards the development of dual binding derivatives for Alzheimer's disease
详细信息 查看全文
- 作者：Laí ; s Flá ; via Nunes Lemesa ; b ; Giselle de Andrade Ramosa ; b ; Andressa Souza de Oliveiraa ; b ; Fernanda Motta R. da Silvac ; Gina de Castro Coutoc ; Marina da Silva Bonic ; Marcos Jorge R. Guimarã ; esc ; Isis Nem O. Souzac ; Manuela Bartolinid ; Vincenza Andrisanoe ; Patrí ; cia Coelho do Nascimento Nogueiraf ; Edilberto Rocha Silveiraf ; Guilherme D. Brandg ; Ondřej Soukuph ; i ; Jan Korá ; bečný ; h ; i ; Nelilma C. Romeiroj ; Newton G. Castroc ; Maria Laura Bolognesid ; marialaura.bolognesi@unibo.it" class="auth_mail" title="E-mail the corresponding author ; Luiz Antonio Soares Romeiroa ; b ; luizromeiro@unb.br" class="auth_mail" title="E-mail the corresponding author
- 关键词：Cashew nut shell liquid ; Alzheimer's disease ; Dual binding site AChE inhibitors ; Acetylcholinesterase ; Multitarget compounds
- 刊名：European Journal of Medicinal Chemistry
- 出版年：2016
- 出版时间：27 January 2016
- 年：2016
- 卷：108
- 期：Complete
- 页码：687-700
- 全文大小：1842 K
文摘
- •
24 novel compounds derived by cardanol were rationally designed and synthesized.
- •
Their inhibitory activities against CHE were assessed and IC50 (μM) determined.
- •
Font">26 showed potency against AChE, low cytotoxicity and capability to cross BBB.
- •
This might be a first step towards innovative and sustainable new medicines for AD.