Administration of SB239063, a potent p38 MAPK inhibitor, alleviates acute lung injury induced by intestinal ischemia reperfusion in rats associated with AQP4 downregulation
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- 作者：Liu-Lin Xionga ; c ; 1 ; Yan Tana ; 1 ; Hong-Yu Maa ; Ping Daib ; Yan-Xia Qind ; Rui-ai Yanga ; Yan-Yan Xua ; Zheng Denga ; Wei Zhaoa ; Qin-Jie Xiac ; Ting-Hua Wangb ; c ; 1 ; tinghua_neuron@263.net" class="auth_mail" title="E-mail the corresponding author ; Yun-Hui Zhanga ; 1 ; yunhuizhang3188@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：ALI ; acute lung injury ; II/R ; intestinal ischemia reperfusion ; MAPK ; mitogen activated protein kinase ; AQP4 ; aquaporin 4 ; SMA ; superior mesenteric artery ; CA ; coeliac artery ; P ; phosphorylated ; WB ; western blot ; IF ; immunofluorescent staining ; NIH ; National Institutes of Health ; SD ; Sprague-Dawley ; IL-1β ; interlukin-1β ; IL-6 ; interlukin-6 ; TNF-alpha ; tumor necrosis factor-alpha ; AQPs ; aquaporins ; HE ; hematoxylin-eosin ; PVDF ; polyvinylidene difluoride
- 刊名：International Immunopharmacology
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：38
- 期：Complete
- 页码：54-60
- 全文大小：1261 K
文摘
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Intestinal ischemia reperfusion (II/R) induced acute lung injury (ALI) in rats.
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Increased level of phosphorylated p38 MAPK and AQP4 in the lung tissues plays important roles in the ALI after II/R.
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SB239063 administration improved ALI after II/R, associated with reduced expression of phosphorylated-p38 MAPK and AQP4.
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p38 MAPK may be one of the pathways mediating AQP4 expression in the ALI induced by II/R.