Early-onset motor impairment and increased accumulation of phosphorylated α-synuclein in the motor cortex of normal aging mice are ameliorated by coenzyme Q
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- 作者：Kazuhide Takahashia ; Ikuroh Ohsawaa ; Takuji Shirasawab ; Mayumi Takahashia ; mmtaka@tmig.or.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：PD ; Parkinson's disease ; CoQ ; coenzyme Q ; Q ; oxidized coenzyme Q ; QH2 ; reduced coenzyme Q ; OCR ; oxygen consumption rate ; α-syn ; alpha-synuclein ; VGluT1 ; vesicular glutamate transporter 1 ; SNc ; substantia nigra pars compacta ; LBs ; Lewy bodies ; TH ; tyrosine hydroxylase
- 刊名：Experimental Gerontology
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：81
- 期：Complete
- 页码：65-75
- 全文大小：1703 K
文摘
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Brain mitochondrial oxygen consumption and coenzyme Q content decreased in aged mice.
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Early-onset motor impairment occurred in normal aging mice.
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Ser129-phosphorylated α-synuclein increased in the motor cortex of aged mice.
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Levels of vesicular glutamate transporter 1 decreased in the motor cortex.
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Coenzyme Q restored motor function and α-synuclein accumulation in aged mice.