Nanoencapsulation of coenzyme Q10 and vitamin E acetate protects against UVB radiation-induced skin injury in mice

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• 作者：Nathá ; li S. Pegoraro^a ; Allanna V. Barbieri^b ; Camila Camponogara^c ; Juliane Mattiazzi^a ; Evelyne S. Brum^c ; Marila C.L. Marchiori^a ; Sara M. Oliveira^c ; Letí ; cia Cruz^a ; ^b ; ^{leticiacruz@smail.ufsm.br} ; ^{leli.cs@gmail.com}
• 关键词：Coenzyme Q10 ; Vitamin E ; Nanocapsules ; Skin ; Ear edema ; UV radiation
• 刊名：Colloids and Surfaces B: Biointerfaces
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：150
• 期：Complete
• 页码：32-40
• 全文大小：2433 K
• 卷排序：150

文摘

Semisolids were obtained by thickening nanocapsule suspensions with gellan gum. The formulations presented characteristics suitable for cutaneous administration. NCP3 decreased MPO and NAGase activity in the UVB radiation-induced ear edema model. NC increased non-protein thiol levels and decreased lipid peroxidation induced by UVB radiation. NC with Q10 and VitE reduced the UVB irradiation-induced effects on skin.