Coenzyme Q10 - A new player in the treatment of heart failure?

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• 作者：Jerzy Jankowski ; Katarzyna Korzeniowska ; Artur Cieślewicz ; ^{artcies@ump.edu.pl" class="auth_mail" title="E-mail the corresponding author} ; Anna Jabłecka
• 关键词：Coenzyme Q10 ; Heart failure ; Supplementation
• 刊名：Pharmacological Reports
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：68
• 期：5
• 页码：1015-1019
• 全文大小：364 K

文摘

Coenzyme Q10 is the only endogenously synthesized lipid with a redox function which exhibits broad tissue and intracellular distribution in mammals. Beneficial effects of Coenzyme Q10 supplementation were observed in several age-related diseases including heart failure. CoQ10 (coenzyme Q10) level is significantly decreased in patients with this disease, which correlates with severity of clinical symptoms. Supplementation with various pharmaceutical formulations of CoQ10 improves impaired cardiac function and clinical course of heart failure. Current data from clinical trials indicate that CoQ10 can significantly reduce morbidity and mortality of heart failure patients in addition to guideline recommended pharmacotherapy.