There is no consensus on how to treat severe and enduring anorexia nervosa (SE-AN). Patients with SE-AN and without SE-AN were treated with inpatient CBT-E. At discharge both groups had improvement of body mass index and psychopathology. At 12-month follow-up more than 40% in both groups had a good BMI outcome. Inpatient CBT-E is a viable and promising treatment for patients with SE-AN.