Deregulation of miRNA-181c potentially contributes to the pathogenesis of AD by targeting collapsin response mediator protein 2 in mice
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- 作者：Huimin Zhoua ; b ; 1 ; Rui Zhanga ; c ; 1 ; Kang Lua ; Wenjun Yua ; Bing Xiea ; c ; Dongsheng Cuia ; Lei Jianga ; Qingfu Zhangc ; Shunjiang Xua ; c ; sjxu66@hotmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Alzheimer's disease (AD) ; MicroRNA ; SAM mice ; Collapsin response mediator protein 2 (crmp2) ; Hippocampus ; miR-181c
- 刊名：Journal of the Neurological Sciences
- 出版年：2016
- 出版时间：15 August 2016
- 年：2016
- 卷：367
- 期：Complete
- 页码：3-10
- 全文大小：846 K
文摘
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MicroRNAs were deregulated in the hippocampal tissue of SAMP8 mice.
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miR-181 levels decreased with aging in the hippocampus tissue.
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miR-181c directly targeted the 3′-UTR of crmp2 mRNA.