Cytokines in saliva increase in head and neck cancer patients after treatment

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• 作者：Nickole Russo ; MS^a ; Emily Bellile ; MS^b ; Carol Anne Murdoch-Kinch ; DDS ; PhD^c ; Min Liu ; MD^a ; Avi Eisbruch ; MD^d ; Greg T. Wolf ; MD^e ; Nisha J. D'Silva ; BDS ; MSD ; PhD^a ; ^f ; ^{njdsilva@umich.edu" class="auth_mail" title="E-mail the corresponding author}
• 刊名：Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：122
• 期：4
• 页码：483-490.e1
• 全文大小：2511 K

文摘

Approximately one-third of advanced head and neck squamous cell carcinomas (HNSCCs) recur within 2 years of treatment. Due to ease of collection, saliva is of interest to monitor changes that correlate with treatment. Previously this was a challenge due to xerostomia after conventional radiation. The emergence of gland-sparing radiation has made it possible to collect saliva post-treatment. This study investigated changes in cytokines in saliva pre- and post-treatment to provide foundational knowledge for future studies exploring the use of saliva to monitor treatment response.

Study Design

Pre- and post-treatment saliva was evaluated for 8 cytokines by multiplex assay and enzyme-linked immunosorbent assay.

Results

In oropharyngeal HNSCC, secretion of epidermal growth factor (EGF), GROα (Growth-regulated protein alpha), interleukin (IL)-1α, IL-β, IL-6, IL-8, tumor necrosis factor-α, and vascular endothelial growth factor increased significantly post-treatment. In additional patients, significant increases of GR-α and IL-6 were validated, but EGF showed no change.

Conclusions

The uniqueness of this study is its comparison of salivary cytokines from HNSCC patients pre- and post-treatment.