Side-chain homologation of nodulisporic acid: synthesis of potent new dienyl derivatives

详细信息    查看全文

• 作者：Ok ; Dong ; Li ; Chunshi ; Shih ; Thomas L. ; Salva ; Steve ; Ayer ; Michelle B. ; Colletti ; Steven L. ; et. al.
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2002
• 出版时间：July 8, 2002
• 年：2002
• 卷：12
• 期：13
• 页码：1751-1754
• 全文大小：126 K

文摘

A series of new, diene-modified nodulisporic acid analogues (2) bearing diverse functionality at the 3″- and 4″-sites was efficiently prepared from the 3″-aldehyde 3. Biological evaluation of these synthetic nodulisporic acid analogues for systemic flea efficacy identified potent compounds and further clarified the structural requirements for ectoparasite activity.