Tryptophan-replacement and indole-modified apicidins: synthesis of potent and selective antiprotozoal agents
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- 作者：Colletti ; Steven L. ; Li ; Chunshi ; Fisher ; Michael H. ; Wyvratt ; Matthew J. ; Meinke ; Peter T.
- 关键词：apicidin ; tryptophan analogs ; selective ; histone deacetylase
- 刊名：Tetrahedron Letters
- 出版年：2000
- 出版时间：October 7, 2000
- 年：2000
- 卷：41
- 期：41
- 页码：7825-7829
- 全文大小：113 K
文摘
A ruthenium tetraoxide catalyzed degradation of apicidin's tryptophan indole provided access to two useful carboxylic acid homolog intermediates. The synthesis of a series of potent and/or selective ketone homologs and 2-arylindoles derived from apicidin is described.