Synthesis of side chain modified apicidin derivatives: potent mechanism-based histone deacetylase inhibitors
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- 作者：Meinke ; Peter T. ; Colletti ; Steven L. ; Ayer ; Michelle B. ; Darkin-Rattray ; Sandra J. ; Myers ; Robert W. ; et. al.
- 关键词：histone deacetylase ; apicidin ; trapoxin ; trichostatin ; inhibitor ; malaria
- 刊名：Tetrahedron Letters
- 出版年：2000
- 出版时间：October 7, 2000
- 年：2000
- 卷：41
- 期：41
- 页码：7831-7835
- 全文大小：86.9 K
文摘
An efficient degradation of apicidin's ketone-containing side chain to two common intermediates (the C7-aldehyde and the C8-methyl ester) is described. From these intermediates, a series of potent mechanism-based histone deacetylase inhibitors was prepared to facilitate biochemical studies.