A simple and efficient approach to the synthesis of 尾-N-methylamino-l-alanine (BMAA)

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• 作者：Enzo B. Aré ; valo-Garcí ; a^a ; ^b ; ^{ebarevalog@gmail.com" class="auth_mail} ; Juan Carlos Colmenares Q.^c ; ¹ ; ^{jcarloscolmenares@ichf.edu.pl" class="auth_mail}
• 关键词：Serine ; Benzyl ; BMAA ; Amino acid
• 刊名：Tetrahedron Letters
• 出版年：9 April, 2014
• 年：2014
• 卷：55
• 期：15
• 页码：2335-2336
• 全文大小：413 K

文摘

A novel, efficient, and straightforward synthesis of 尾-N-methylamino-l-alanine (BMAA) in two steps starting from l-N,N-dibenzylserine benzyl ester is described. This method, in the light of other syntheses of BMAA, provides benefits such as mild reaction conditions, a simple work-up procedure, good yields, and the retention of the serine stereochemistry.