Inflammation, genes and zinc in Alzheimer's disease
详细信息 查看全文
- 作者：Sonya Vasto ; Giuseppina C ; ore ; Florinda Listì ; Carmela Rita Balistreri ; Giuseppina Colonna-Romano ; Marco Malavolta ; Domenico Lio ; Domenico Nuzzo ; Eugenio Mocchegiani ; Danilo Di Bona ; Calogero Car
- 关键词：Alzheimer's disease ; Immunogenetic ; Inflammation ; Zinc
- 刊名：Brain Research Reviews
- 出版年：2008
- 出版时间：June 2008
- 年：2008
- 卷：58
- 期：1
- 页码：96-105
- 全文大小：336 K
文摘
Alzheimer's disease (AD) is a heterogeneous and progressive neurodegenerative disease which in Western society mainly accounts for clinical dementia. AD has been linked to inflammation and metal biological pathway. Neuro-pathological hallmarks are senile plaques, resulting from the accumulation of several proteins and an inflammatory reaction around deposits of amyloid, a fibrillar protein, Aβ, product of cleavage of a much larger protein, the β-amyloid precursor protein (APP) and neurofibrillary tangles. Amyloid deposition, due to the accumulation of Aβ peptide, is the main pathogenetic mechanism. Inflammation clearly occurs in pathologically vulnerable regions of AD and several inflammatory factors influencing AD development, i.e. environmental factors (pro-inflammatory phenotype) and/or genetic factors (pro-inflammatory genotype) have been described. At the biochemical level metals such as zinc are known to accelerate the aggregation of the amyloid peptide and play a role in the control of inflammatory responses. In particular, zinc availability may regulate mRNA cytokine expression, so influencing inflammatory network phenotypic expression.