Disordered zonal and cellular CYP11B2 enzyme expression in familial hyperaldosteronism type 3

详细信息    查看全文

• 作者：Celso E. Gomez-Sanchez^a ; ^b ; ^{cgomez-sanchez@umc.edu} ; Xin Qi^b ; Elise P. Gomez-Sanchez^c ; Hironobu Sasano^d ; Martin O. Bohlen^e ; Max Wisgerhof^f
• 关键词：Primary aldosteronism ; Aldosterone ; CYP11B2 ; KCNJ5 ; CYP17A1
• 刊名：Molecular and Cellular Endocrinology
• 出版年：2017
• 出版时间：5 January 2017
• 年：2017
• 卷：439
• 期：Complete
• 页码：74-80
• 全文大小：3038 K
• 卷排序：439

文摘

Immunohistochemistry of 2 cases of familial hyperaldosteronism 3 are described. CYP11B2 is expressed heterogeneously throughout the adrenal. CYP11B2 is co-expressed in cells with KCNJ5 and in many cells with CYP11B1. CYP11B2 is co-expressed in some cells with the 17α-hydroxylase.