Herpesvirus Saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor

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• 作者：Zhengbin Yao ; William C. Fanslow ; Michael F. Seldin ; Anne-Marie Rousseau ; Sally L. Painter ; Michael R. Comeau ; Jeffrey I. Cohen ; Melanie K. Spriggs
• 刊名：Immunity
• 出版年：1995
• 出版时间：December 1995
• 年：1995
• 卷：3
• 期：6
• 页码：811-821
• 全文大小：1866 K

文摘

Herpesvirus Saimiri gene 13 (HVS13) exhibits 57 % identity with the predicted sequence of a T cell-derived molecule termed CTLAB. Recombinant HVS13 and CTLA8 stimulate transcriptional factor NF-κB activity and Interleukin-6 (IL-6) secretion in fibroblasts, and costimulate T cell proliferation. An HVS13.Fc fusion protein was used to isolate a cl)NA encoding a novel receptor that also binds CTLA8. This receptor is unrelated to previously Identified cytokine receptor families. A recombinant soluble receptor inhibited T cell proliferation and IL-2 production Induced by PHA, concanavalin A (conA), and anti-TCR MAb. These results define CTLA8 and HVS13 as novel cytokines that bind to a novel cytokine receptor. We propose to call these molecules IL-17, vIL-17, and IL-17R, respectively.