Obesity paradox in patients with community-acquired pneumonia: Is inflammation the missing link?

详细信息    查看全文

• 作者：Nina Braun ; M.D.^a ; ^b ; Claus Hoess ; M.D.^a ; Alexander Kutz ; M.D.^b ; Mirjam Christ-Crain ; M.D. ; Ph.D.^c ; Robert Thomann ; M.D.^d ; Christoph Henzen ; M.D.^e ; Werner Zimmerli ; M.D.^f ; Beat Mueller ; M.D.^b ; ^g ; Philipp Schuetz ; M.D. ; M.P.H.^b ; ^g ; ^{Schuetzph@gmail.com}
• 关键词：Obesity paradox ; Pneumonia ; Inflammation
• 刊名：Nutrition
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：33
• 期：Complete
• 页码：304-310
• 全文大小：378 K
• 卷排序：33

文摘

Obesity is generally considered to be a major risk factor for a number of diseases; however, in certain patient populations, it is paradoxically associated with improved survival in a phenomenon called the “obesity survival paradox.” We were able to show the obesity paradox in our cohort of community-acquired pneumonia patients, in whom 6-y survival was significantly improved in those who were obese. There is no association between obesity and inflammation biomarkers that explains this paradox. Further studies are needed to define the underlying mechanism of the obesity paradox.