Low level of mono(2-ethylhexyl) phthalate reduces oocyte developmental competence in association with impaired gene expression

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• 关键词：Phthalates ; MEHP ; Oocyte developmental competence ; Gene expression
• 刊名：Toxicology
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：377
• 期：Complete
• 页码：38-48
• 全文大小：1306 K
• 卷排序：377

文摘

Low doses of MEHP impair oocyte developmental competence and transcript expression A prominent effect of MEHP was found when oocytes were cultured in the absence estradiol. Although it was the oocyte that was exposed to MEHP, effects were carried over to the blastocyst stage. The findings suggest that low levels of phthalate must be taken into consideration in risk assessments.