Qualitative and quantitative assessment of self-reported cognitive difficulties in nondemented elders: Association with medical help seeking, cognitive deficits, and β-amyloid imaging

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• 作者：Renaud La Joie^a ; ^b ; ^c ; ^d ; ^{lajoie@cyceron.fr} ; Audrey Perrotin^a ; ^b ; ^c ; ^d ; Sté ; phanie Egret^a ; ^b ; ^c ; ^d ; Florence Pasquier^e ; ^f ; Clé ; mence Tomadesso^a ; ^b ; ^c ; ^d ; Florence Mé ; zenge^a ; ^b ; ^c ; ^d ; Bé ; atrice Desgranges^a ; ^b ; ^c ; ^d ; Vincent de La Sayette^a ; ^b ; ^c ; ^g ; Gaë ; l Ché ; telat^a ; ^b ; ^c ; ^d
• 关键词：Subjective cognitive decline ; Memory complaint ; β-Amyloid ; Positron emission tomography ; Preclinical ; Biomarkers ; Anosognosia ; Prodromal Alzheimer's disease ; Mild cognitive impairment ; Orientation
• 刊名：Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
• 出版年：2016
• 出版时间：2016
• 年：2016
• 卷：5
• 期：Complete
• 页码：23-34
• 全文大小：1372 K
• 卷排序：5

文摘

Subjective cognitive decline (SCD) could help identify early stages of Alzheimer's disease. However, SCD is multidetermined and protean, and the type of cognitive complaint associated with preclinical Alzheimer's disease needs refinement.MethodsA total of 185 nondemented elders recruited from either the community or from a memory clinic filled a questionnaire. We searched for item responses associated with medical help seeking, cognitive deficits, and β-amyloidosis.ResultsCompared with community-recruited control subjects (n = 74), help-seeking patients reported a stronger multidomain SCD that was mostly unrelated to the presence of detectable cognitive deficits. Only a few items, notably assessing temporal disorientation, distinguished help-seeking patients with (n = 78) or without (n = 33) memory deficits. Associations between SCD and β-amyloidosis were not restricted to the memory domain and varied across clinical stages.DiscussionDetailed evaluation of SCD could provide accessible indication of the presence of β-amyloid or cognitive deficits, which might prove useful for early diagnosis and clinical trial enrichment strategies.