文摘
The interaction of CRP, SAP, and PTX3 with collectin CL-P1 activates complement mainly through the classical pathway. Initiation of the classical pathway provokes the alternative pathway and the properdin dependent amplification pathway. CRP and PTX3 recruit CFH while SAP recruits C4BP on CL-P1 surfaces to prevent TCC formation. CFH, C4BP and CFI depleted serum failed to prevent TCC formation on CL-P1.