Molecular Basis of Assembly and Activation of Complement Component C1 in Complex with Immunoglobulin G1 and Antigen
详细信息 查看全文
- 作者：Guanbo Wang1 ; 2 ; 6 ; Rob N. de Jong3 ; 6 ; Ewald T.J. van den Bremer3 ; Frank J. Beurskens3 ; Aran F. Labrijn3 ; Deniz Ugurlar4 ; Piet Gros4 ; Janine Schuurman3 ; Paul W.H.I. Parren3 ; 5 ; 7 ; p.parren@genmab.com" class="auth_mail" title="E-mail the corresponding author ; Albert J.R. Heck1 ; 2 ; 7 ; a.j.r.heck@uu.nl" class="auth_mail" title="E-mail the corresponding author
- 刊名：Molecular Cell
- 出版年：2016
- 出版时间：7 July 2016
- 年：2016
- 卷：63
- 期：1
- 页码：135-145
- 全文大小：2015 K
文摘
- •
Complement components C1q and C1 bind efficiently to soluble IgG hexamers
- •
IgG glycosylation contributes to both the hexamer stability and C1q binding
- •
A complement initiation complex is reconstituted and visualized by mass spectrometry