This study compared the gene expression profiles of human coronal pulp (CP) and the apical pulp complex (APC) with the aim of elucidating whether any differences found can explain differences in their functions.
The apical papilla and covering follicular tissue were inseparably related to each other and function as a unit.
The expression levels of genes related to dentin mineralization, neurogenesis, and neurotransmission were higher in the CP in human immature teeth, whereas those of immune-related and tooth development–related genes were higher in the APC.