Role of estradiol in intrinsic hindbrain AMPK regulation of hypothalamic AMPK, metabolic neuropeptide, and norepinephrine activity and food intake in the female rat
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- 作者：F.S.H. Alenazi ; B.A. Ibrahim ; H. Al-Hamami ; M. Shakiya ; K.P. Briski ; briski@ulm.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：AICAR ; 5-aminoimidazole-4-carboxamide-riboside ; AMPK ; adenosine 5&prime ; -monophosphate-activated protein kinase ; ARH ; arcuate hypothalamic nucleus ; AVPV ; anteroventral periventricular nucleus ; Cc ; compound C ; cDVC ; caudal DVC ; CV4 ; caudal fourth ventricle ; DMH ; dorsomedial hypothalamic nucleus ; DVC ; dorsal vagal complex ; EDTA ; ethylenediaminetetraacetic acid ; ELISA ; enzyme-linked immunosorbent assay ; LHA ; lateral hypothalamic area ; MPN ; medial preoptic nucleus ; NE ; norepinephrine ; O.D. ; optical
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：9 February 2016
- 年：2016
- 卷：314
- 期：Complete
- 页码：35-46
- 全文大小：1967 K
文摘
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Compound C (Cc) was injected to estradiol- or oil-implanted ovariectomized rat hindbrain.
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Cc inhibits hindbrain adenosine 5′-monophosphate-activated protein kinase (AMPK).
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Estradiol regulates hindbrain Cc effects on hypothalamic AMPK.
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Estradiol determines hypothalamic targets of Cc-altered norepinephrine signaling.
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Cc completely or partially represses feeding in presence versus absence of estradiol.