Pleiotropic effects of gold(I) mixed-ligand complexes of 9-deazahypoxanthine on transcriptional activity of receptors for steroid hormones, nuclear receptors and xenoreceptors in human hepatocytes and cell lines
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- 作者：Kateřina Kube&scaron ; ová ; a ; Zdeněk Trá ; vní ; čekb ; Zdeněk Dvořá ; ka ; moulin@email.cz" class="auth_mail" title="E-mail the corresponding author
- 关键词：Nuclear receptors ; Human hepatocytes ; Cytochrome P450 ; Gold complexes ; Xenobiotics
- 刊名：European Journal of Medicinal Chemistry
- 出版年：2016
- 出版时间：4 October 2016
- 年：2016
- 卷：121
- 期：Complete
- 页码：530-540
- 全文大小：2344 K
文摘
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Gold(I) complexes exert a plethora of biological activities.
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Effects of gold(I) complexes on nuclear, steroid and xeno-receptors were studied.
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Gold(I) complexes are inverse agonists of VDR and AR receptors.
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Gold(I) complexes are antagonists of glucocorticoid receptor.
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Gold(I) complexes are moderate activators of AhR and PXR.