Airway distension during lung inflation in healthy and allergic-sensitised mice in vivo

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• 作者：Toshihiro Sera^a ; ^b ; ^{sera@me.es.osaka-u.ac.jp} ; Hideo Yokota^b ; Kentaro Uesugi^c ; Naoto Yagi^c
• 关键词：Airway kinematics ; Airway compliance ; Hyperresponsiveness ; Synchrotron radiation ; Computed tomography
• 刊名：Respiratory Physiology & Neurobiology
• 出版年：2013
• 出版时间：1 February, 2013
• 年：2013
• 卷：185
• 期：3
• 页码：639-646
• 全文大小：1315 K

文摘

We evaluated the airway distention during lung inflation of varying size in healthy and allergic-sensitised mice in vivo. Computed tomography (CT) images of healthy and ovalbumin-treated mice were acquired using a synchrotron in vivo CT system when lung pressures was 0 and 20 cmH₂O, and the morphometric distension (diameter, length, and volume) and the compliance of airway segments (to as small as ¡«150 ¦Ìm internal diameter) were calculated. With respect to airway size, in healthy mice, the changes in airway diameter and compliance were larger in the small-airway group. In contrast, in allergic-sensitised mice, there were no significant differences in the changes in airway distension or compliance. Airway wall thickness in allergic-sensitised mice increased significantly in all airway groups, but the change was much larger in the small than in the large-airway group. Compared with healthy airways, the changes in diameter and airway compliance of the allergic-sensitised mice were significantly smaller in the small-airway group.