Nucleophilic monofluoroalkylation with fluorinated phosphonium salt toward carbonyl and imine compounds

详细信息    查看全文

• 作者：Xian-Liang Zeng^a ; ^b ; Zu-Yong Deng^b ; Can Liu^b ; Gang Zhao^b ; Jin-Hong Lin^b ; ^{jlin@sioc.ac.cn} ; Xing Zheng^a ; ^{zhengxing5018@yahoo.com} ; Ji-Chang Xiao^b ; ^{jchxiao@sioc.ac.cn}
• 关键词：Nucleophilic ; Monofluoroalkylation ; Phosphonium salt ; Substituent
• 刊名：Journal of Fluorine Chemistry
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：193
• 期：Complete
• 页码：17-23
• 全文大小：851 K
• 卷排序：193

文摘

A fluorinated substituent on the positive phosphorus in phosphonium salt [Ph3P+CF(Me)CO2Et Br−] was found to be able to act as a nucleophile. An efficient nucleophilic monofluoroalkylation agent was developed. The nucleophilic monofluoroalkylation reaction can be applied to aldehydes, ketone and imine.